Clay Siegall makes huge contributions to the field of antibody drug conjugates

Prior to the 1930s, a diagnosis of cancer was often a death sentence. Most patients did not survive more than about six months from the onset of the first symptoms. This was almost independent of the cancer type. These patients often were treated only with palliative care, which usually involved little more than pumping them full of morphine or other opioids.

But then novel treatments started coming online . Throughout the ‘30s and ‘40s, it first became known that cancer could be successfully fought with the use of radiation and excision of the tumor site. Gradually, survival rates begin to improve. For some types of cancer, such as breast cancers, the survival rates dramatically improved throughout the 50s and ‘60s. It was in those decades that the first chemotherapies began becoming available.

However, even though these chemotherapies dramatically increased the survivability of certain types of cancers, they often entailed extremely brutal side effects and left patients with permanent damage, including things such as paresthesia and what’s known as chemo-brain, a fogginess of thought, which, in extreme cases, can be almost indistinguishable from dementia.

But for many types of cancer, survival rates did not significantly improve, right through the 1990s. Then a man by the name of Clay Siegall came along with a new solution. Rather than pumping the entire body full of the dangerous poison called chemotherapy, Dr. Siegall thought that it might be possible to specifically target the tumor tissue, only releasing the cytotoxic agent upon direct contact with the tumor site. In theory, this could completely eliminate the side effects of traditional chemotherapy regimens.

In 1998, Dr. Siegall founded Seattle Genetics, a pharmaceutical company dedicated to the development of targeted cancer therapies and specifically, a class of drugs known as antibody drug conjugates. These drugs use the body’s own immune system to identify and target tumor sites. Through the use of a modified antibody that is bound to a cytotoxic agent, antibody drug conjugates are capable of targeting only the tumor site, virtually eliminating the systemic release of dangerous chemotherapeutic agents into the bloodstream.

This revolutionary class of drugs has the power to completely change the way cancer is treated.

June 6, 2017 | Category: ADC

The Generosity of Dick DeVos

Dick DeVos is a man with many talents as well as many goals for the future and for the legacy of his family name that is known as DeVos. The DeVos family name is a growing name that was first created when the family company of Amway Corporation was founded by Richard DeVos. Over the past several decades, the family business has grown at an exponential rate to experience success and to become a multi-billion dollar corporation that has been fully integrated into countries all over the world. Of the many prominent members of the DeVos family, Dick DeVos, Betsy Devos, and Richard DeVos are some of the most distinguished members of the family.


Dick DeVos is the son of Richard DeVos, the founder and the creator of Amway Corporation. Dick DeVos has many talents as well as many titles including that of a successful businessman, a beloved family man, as well as a philanthropist who has made sure that millions of individuals across the United States experience a piece of his success over the years. Dick DeVos, though a well respected businessman, has loved giving back to communities across the United States even more. Dick DeVos has always see success as a subjective value that can only be defined by how much of one’s wealth is given back to enrich communities.


Dick DeVos has loved the idea and the career of business ever since he was a young boy. Dick DeVos had the fortune to be able to watch the vast and successful company grow from a small company that was held in the basement of his family home to an international and multi-billion dollar company. Dick DeVos has been extremely proud of what he and his employees have accomplished and hopes that the legacy of the DeVos family will continue to expand and be a respected legacy.


Though Dick DeVos is a businessman, he is also a philanthropist who is passionate about the education initiative. Dick DeVos has had plans to improve the education system across the country and to make sure that opportunities are offered to children who come from different backgrounds. Dick DeVos believes that education should be based upon merit and should not be based upon the level of income that a family makes on an annual basis. Dick DeVos has donated millions of dollars to fund scholarships and to even fund the building of schools.


Passive Fund Management is Not Always the Safest Bet

Tim Armour, the well-known fund manager of American Funds took to CNBC to write a response to Warren Buffett’s claim that passive fund management is most often the safest bet, and is also usually the smartest choice. Buffett claims that the majority of actively managed mutual and hedge funds are inefficient and that investors would be well served to choose a passively managed fund. In addition to stating that this is the safest way to go, Buffett also put forth the challenge that it is also the path that will bring the greatest level of returns. Tim Armour disputes this claim and respectfully disagreed with the Oracle from Omaha.

Armour does agree that there are a number of mismanaged funds that do get regularly out-performed by the market indices but he does not agree that this result is always the case. Yes, there are funds that charge exorbitant fees and that execute trades that are unwise and end up being costly, but Armour’s argument is that there are plenty of incidences where this is decidedly not the case. He believes that there are a good number of actively managed funds out there that consistently out-perform the markets.

While many people focus on the safety of passive funds, Armour brings up a very relevant point about the number of opportunities that are missed due to this passive management. In addition to being risk averse, passive funds can also create an environment where they are also growth-averse. By doing nothing but tracking the market, these funds can miss out on many smart trades that when executed in an efficient manner can create many significant returns. When active funds are properly managed without these inflated fees and nonsense trades, Armour believes that they will consistently beat the market.Warren Buffett is one of our nation’s very best financial advisors, and taking a position that does not agree with him 100% is not done very often, if at all!

The Successful Road of Anthony (Tony) Petrello

Anthony Petrello (also known as Tony) began his professional journey in 1979 when he joined the law firm of Baker and McKenzie. In 1986, Anthony became the firm’s Managing Partner of their New York Office. He maintained this position until 1991 when he joined Nabor Industries, Ltd. as Chief Operating Officer. In 1992 he became the President of Nabor Industries Ltd. In 2003, Anthony held the position of Deputy Chairman at Nabor Industries, and held this position until June, 2012. During his stint as Deputy Chairman, he also held the position of Chief Executive Officer in 2011. In February of that same year Anthony held the office of Director at Stewart and Stevenson, LLC.

Along with a successful professional career, Anthony has Board memberships with many agencies including, Texas Children’s Hospital, Houston Museum of Fine Arts and Stewart and Stevenson LLC, National Petroleum Council, and the Council on Foreign Relations.

With regards to his educational background, Anthony Petrello attended and graduated from Harvard University Law School where he earned his Juris Doctor degree. He also is a graduate of Yale University where he received his Bachelor of Science (BS) and his Master of Science (MS) degrees in Mathematics.

On a personal note, Anthony had a roommate, Lloyd Grove who wrote an article for the Daily Beast. In this, Lloyd describes Petrello as a mathematics whiz who has gone on to become one of the highest CEOs in the US. He goes on to say that Tony Petrello was a skinny scholarship kid from Newark with a thick Jersey accent. He was an Italian-American with an extrovert personality who was very fond of pizza. He enjoyed joking about his family and quick to laugh during mealtime with friends. He was very good at mathematics and the favorite student of Professor Serge Lang who was a renown world class mathematician.


The Real Norman Pattiz



Who is the real Norman Pattiz? He is a man known for many things. And, it appears that he is a man good for doing anything possible if podcasts are involved. He has a lot of energy for projects that bring crowds of attention and even more so for those projects that can endure long enough to make themselves legacy. Of course, the absolute best situation is when a project does both of those things and generates revenue. When the results come in, they almost always indicate that podcast are a major new wave in the business of entertainment and advertisement.


The key information to navigating podcast programming and promotion is to understand that podcast audiences listen keenly. They also want things that genuinely improve the quality of their lives. This suggests that they are educated and working professionals who need to stay ahead of the cutting edge. Other findings suggest that many podcast audience members are home owners who are in need of some kind of service to streamline their lifestyle. In essence, they want something new. Ultimately, pitching quality service and products is just as effective as giving them a brand name they already know. This information, gathered by Edison Research, is crucial to businesses like PodcastOne.


As the founder of PodcastOne, using information such as this to orchestrate successful business ventures is precisely what Mr. Pattiz does for a career. But, it is not just all about pushing the same old cheesy shows and commercials on audiences. There is a finesse to it. There has to be the right mix of current events, popular music, sports, education, comedy, politics, the miscellaneous and a little bit of razzle-dazzle. But, somehow he makes it all work out for the best. How does he do it?


The first thing to know about how Norman Pattiz makes things happen is to understand that there is no typical day for him or his team of people. Except, there is one thing that you can absolutely count on. He gets involved with everything possible, as far as PodcastOne is concerned. His ideology for success is all about implementation, especially for a small company such as his. However, he also knows the value of collaboration and flexibility in business practices. He is super excited about the new ways to pinpoint consumer demographics and bring them the things they need through marketing designs. In that many of his mentors are no longer with us, this pioneer and leader is one of a kind.

Learn more:

Samuel Strauch: An Expert For Your Real Estate Needs

Samuel Strauch is an active investor in numerous restaurant and online business. He is also an art and photography lover who did not take any formal education in art and photography, but still, people still claim that the picture taken by him are one of the ideals portray of proper meaning and message that he wants to convey through those pictures. Samuel Strauch took his formal education at Hofstra University in business by studying at his New York campus. He also completed few professional courses from Harvard University.

Samuel Strauch wanted to be a self-made man, and for that purpose, he tried to start a new business, and he was running it very well. But he never knows that one day he will be back to his forefather’s business i.e. real estate business. When he was working hard and trying to take his business to new heights, due to some reason he had to come back to what he was destined for, his family business of Real Estate in South Florida.

SO, in 2002, Samuel Strauch founded his own company, Metrik Real Estate and worked hard to make it a reliable and trustworthy name in whole Florida when it is about real estate. His company offers services in in equity acquisitions, sourcing, management, brokerage and development of real estate in Latin America along with the South Florida.

Related: Samuel Strauch on the ePodcast Network

Metrik is a forward thinking and progressive company that based in South Beach, Florida. A vertically integrated platform by Metrik is divided into few crucial areas: Brokerage, Equity and Development and the Management. Metrik ultimately expanded operations in many Latin American countries to offer world class real estate services to not just the local of Florida, US but the client all across the globe. The success of Metrik has been achieved by the teamwork of each and every employee under the leadership of Samuel Strauch through their hard work and dedications.


Fashion Takes Steps To A Diverse Future With Kate Hudson’s Fabletics Brand

These days, a lot of people are dressed to look like one another. In some cases, they are dressed in ways that are uninspired. One of the issues that influence this is the fact the mindset behind fashion. Many people have a funny mindset when it comes to clothing. One of the common issues that people have been faced with is money and time. Also, a lot of people have been made to believe that there is only one way that people can dress well. As a result, people have dropped the idea of fashion altogether. Fortunately, there are people like Kate Hudson that are bringing about a change in mentality when it comes to fashion.


A lot of designers believe that it is time for a change in fashion. Among the designers and stylish people that are trying to bring forth change is Kate Hudson. She is working very hard to bring fashion into a future of diversity as she is encouraging people to find their own sense of style and be different from others. This not about being different just to be different, it is more about self expression. After all, people communicate about themselves with their appearances.


However, the ability for self expression does need to expand for some people. Kate Hudson herself knows that there are some people that are very creative when it comes to putting outfits together. However, their creativity is limited by the options that are available. Therefore, Kate Hudson has used her connections and her status to build a brand that allows people to explore their own creativity in fashion. This brand is called Fabletics. They have a ton of new athletic items that bring about an extra sense of style and spiciness to the athletic section of the fashion industry.


When it comes to fashion and style, some people feel that they have to be boring or weird in order to be considered well dressed or stylish. However, Kate Hudson encourages people to dress in ways that represent who they are. Therefore, one does not have to be stuffed in loud outfits so that they can be considered stylish. At the same time, one should not be worried about what others think about them. People do not wear Fabletics or other forms of stylish clothing for others. It is important for people to dress in ways that make them feel at their best and most authentic.

Weekend #workout plan inspired by @gingerressler's high-power moves ????

A video posted by @fabletics on

A Look At Financial Expert Brad Reifler

Brad Reifler has been in the financial industry for over 30 years. Early in his career, he founded his first financial firm, Reifler Trading Corporation, in 1982. He went on to found his own financial services company, Pali Capital. He is also the founder of Forefront Income Trust.

Pali Capital was founded by Brad Reifler in 1995. While serving as the Chairman of the Board and Chief Executive Officer he led the company to into being a large player in the financial world. Pali Capital grew from a small company to one that was increasing its annual revenues by $200 million a year. Reifler also expanded the company from its headquarters in New York to one that had offices in the United Kingdom, Singapore, Austria, and South America.

It was in January 2014 that Brad Reifler founded and serves as the CEO of ForeFront Income Trust, also based in the city of New York. While to this point in his career he had worked with high net worth individuals, Reifler’s focus at ForeFront Income trust is to help middle-class clients save for retirement and other financial goals.

There are classes of assets that the United States government only allows the richest 1% to invest in. According to Crunchbase, Brad Reifler is able to make these alternative investments available to regular investors. Learn more about Brad Reifler:

The premise of ForeFront Income Trust is that their fund makes nothing at all until the fund investor has earned 8%. The fund is also not correlated with the stock or bond markets which give investors more diversity in their portfolio. Additionally, Reifler donates 3% to veterans and military families when investors invest directly into the fund.

In addition to Forefront Income Trust, Brad Reifler also oversees its subsidiaries including ForeFront Advisory, LLC, and ForeFront Partners. He also sits on several corporate and advisory boards for other financial firms.

Bloomberg revealed that Brad Reifler is also a former Trustee of the MillBrook School and was the Chairman of its Financial Committee. Reifler graduated in 1981 from Bowdoin College with Bachelor’s Degrees in Economics and Political Science.


Taste The Class

Do you like good wine? Do you like luxury? Do you also have expensive taste? If so, than UKV PLC wines may be just the thing that’s missing in your life! What is UKV PLC wines you ask?

UKV PLC is an independent and privately run wine company based out of the UK who specializes in buying and selling the most upscale wines and champagnes. They have a small team of dedicated wine connoisseurs to help offer you the very best of the best for any and all of your fine drinking needs.

UKC PLC works with you by offering up their knowledge and expertise to ensure you get the right wine or champagne for any occasion. They can even arrange face to face meetings where you can meet up at one of their locations, or if you don’t feel like leaving home they will meet with you personally, at a place of your choosing. Now that’s fancy!

Since UKV PLC is an independent wine company that isn’t limited by a single wine chain, they have more to offer than one might think. They carry UKV PLC vintage wines such as Chateau Lafite, Mouton Rothschild, Lafite Rothschild, and Latous. They buy the most prestigious wines and champagnes from vineyards in Italy, Spain, and France, and their selection is truly limitless.

There are many benefits that can be had from buying wine and champagne through UKV PLC. Wine collectors and connoisseurs alike can not only buy for consumption and enjoyment, but also invest in UKV’s regulated wine bonds through the company’s brokerage service. The supply and sale of bonded fine wines can also be traded by both private and trade customers, which means you may switch that old bitter duplicate for a fresh new wine that’s ripe and ready for your pallet. With UKV your order is sure to come through, to ensure that your needs are always met.

Looking to step up your game and become a member? Investing in quality grade wine is a lot like owning real estate. You have complete control and ownership over something that is considered a highly exclusive market. Wine can both go up and down in value, like most things, and there isn’t a guarantee that a wine’s potential value will always increase. Luckily UKV’s consultants are there to help advise and assist with any questions you may have in choosing the right wine to invest in, so that you can come out on top.

You can find out more information on UKC PLC wines through their direct website You can also follow them on Twitter @UkvPlc, on Instagram @ukv_plc, on Facebook and even LinkedIn. So choose UKC PLC wines, and always keep it classy.

The Quincy: A Hot Bed Of Criminal Activity, New Brunswick, NJ

The Quincy is an apartment complex located in downtown New Brunswick, NJ. The apartment complex designed for the residence of the working class singles and families to reside in; however, despite it’s posh and contemporary look, the Quincy is considered to be an unsafe place for its residence. Several criminal incidences have accorded at the Quincy over the years. The frequency in which these criminal activities keep happening at this complex has made the place unsafe for its residences. The top two notorious criminal incidences to occur at the Quincy are the pizza robbery in 2013 and the shooting in 2015.


The pizza robbery occurred on May 7, 2013. A pizza delivery guy was robbed and shot while attempting to deliver pizza at the Northern building in Quincy Circle apartment complex. The residents told him that no one ordered pizza. When going back to his car the pizza delivery guys encountered three men who proceeded to rob him of the pizza and his wallet and then shot him. Eyewitnesses reported seeing the three robbers escape in a dark colored minivan. Later on, it was discovered that the individuals involved in the robbery and shooting were the 21-year old Parysh Wood—a notorious gangster in his community— and his friends.


The shooting occurred on October 7, 2015. Gunshots were reported to be heard around the Quincy. At least four shootings were heard, and one person sustained a minor injury and had to be taken to the nearest hospital. Police found various bullets at the scene of the crime. According to police, criminal incidents like the shooting and robbery are common at the Quincy complex